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Patients receiving ARIMIDEX had a decrease in hot flashes, vaginal bleeding, vaginal discharge, endometrial cancer, venous thromboembolic events and ischemic cerebrovascular events compared with patients receiving tamoxifen.

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The cumulative incidences of all first fractures (both serious and non-serious, occurring either during or after treatment) was higher in the Arimidex group (15%) compared to the tamoxifen group (11%).

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